We are willing to contribute to the global advancement of the pharmaceutical industry.
Cooperated with senior experts at home and abroad, our technical experts submitted or accepted contributions to influential journals and magazines of life and sciences and medicine in the domestic and foreign industries, including Methods, Enzyme and Microbial Technology, Applied Microbiology and Biotechnology. We published a number of academic papers to share research results with the industry and provide important references for industrial progress.




(Year)Vol.: pp.(or Article number)

 A Rational Designed Novel Bispecific Antibody for the Treatment of GBM Biomedicines  (2021)9, 640

RPL21 siRNA Blocks Proliferation in Pancreatic Cancer Cells by Inhibiting DNA Replication and Inducing G1 Arrest and Apoptosis

Frontiers in Oncology (2020)10,1730
A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer Journal of Experimental & Clinical Cancer Research  (2020)39, Article number:87

Bioprocess development of a stable FUT8-/--CHO cell line to produce defucosylated anti-HER2 antibody

Bioprocess and Biosystems Engineering (2019)42:1263-1271

Development of a recombinant human IL-15·sIL-15Rα/Fc superagonist with improved half-life and its antitumor activity alone or in combination with PD-1 blockade in mouse model

Biomedicine & Pharmacotherapy


A general platform for efficient extracellular expression
and purification of Fab from Escherichia coli

Applied Microbiology and Biotechnology (2019)103:3341-3353

Reduction of non-specific toxicity of immunotoxin by intein mediated reconstitution on target cells

International Immunopharmacology (2019)66:288-295
Naturally split intein Npu DnaE mediated rapid generation of bispecific igG antibodies Methods (2019)154:32-37
Intermolecular disulfide bonds between unpaired cysteines retard the C-terminal trans-cleavage of Npu DnaE Enzyme and Microbial Technology (2018)118:6-12
Rapid development of stable transgene CHO cell lines by CRISPR/Cas9 mediated site-specific integration into C12orf35 Applied Microbiology and Biotechnology (2018)102:6105-6117
Enhanced production of anti-PD1 antibody in CHO cells through transient co-transfection with anti-apoptotic genes Bcl-xL and Mcl-1 Bioprocess and Biosystems Engineering (2018)41:633-640
Local and Global Anatomy of Antibody-Protein Antigen Recognition Journal of Molecular Recognition (2018)31,issue 5:e2693
Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patients BBA - Molecular Basis of Disease (2018)6 Pt B:2294-2303
Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system Scientific Reports (2017)7, Article number:8630
Purification of Inclusion Bodies Using PEG Precipitation under Denaturing Conditions to Produce Recombinant Therapeutic Proteins from Escherichia coli Applied Microbiology and Biotechnology (2017)101:5267-5278

Producing defucosylated antibodies with
enhanced in vitro antibody-dependent cellular
cytotoxicity via FUT8 knockout CHO-S cells

Engineering in Life Sciences (2017)17:801-808
Production process reproducibility and product quality consistency of transient gene expression in HEK293 cells with anti-PD1 antibody as the model protein Applied Microbiology and Biotechnology (2017)101:1889-1898
A novel self-cleavable tag Zbasic-∆I-CM and its application in the soluble expression of recombinant human interleukin-15 in Escherichia coli Applied Microbiology and Biotechnology (2017)101:1133-1142
Functional knockout of FUT8 in Chinese hamster ovary cells using CRISPR/Cas9 to produce a defucosylated antibody Engineering in life science (2015)15:660-666
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