发表论文

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我们的技术专家与国内外资深业界专家通力合作,公司在包括Methods、Enzyme and Microbial Technology、Applied Microbiology and Biotechnology等国内外业界具有影响力的生命科学与医学杂志、期刊上投稿或接受约稿,发表有多篇学术论文,将研究成果分享业界,为产业进步提供重要的参考文献。




论文列表

(仅提供英文)

 

Titles

Journals

(Year)Vol.: pp.(or Article number)

RPL21 siRNA Blocks Proliferation in Pancreatic Cancer Cells by Inhibiting DNA Replication and Inducing G1 Arrest and Apoptosis

Frontiers in Oncology (2020)10,1730
A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer Journal of Experimental & Clinical Cancer Research  (2020)39, Article number:87

Bioprocess development of a stable FUT8-/--CHO cell line to produce defucosylated anti-HER2 antibody.

Bioprocess and Biosystems Engineering (2019)42:1263-1271

Development of a recombinant human IL-15·sIL-15Rα/Fc superagonist with improved half-life and its antitumor activity alone or in combination with PD-1 blockade in mouse model.

Biomedicine & Pharmacotherapy

(2019)112-108677

A general platform for efficient extracellular expression
and purification of Fab from Escherichia coli

Applied Microbiology and Biotechnology (2019)103:3341-3353

Reduction of non-specific toxicity of immunotoxin by intein mediated reconstitution on target cells

International Immunopharmacology (2019)66:288-295
Naturally split intein Npu DnaE mediated rapid generation of bispecific igG antibodies Methods (2019)154:32-37
Intermolecular disulfide bonds between unpaired cysteines retard the C-terminal trans-cleavage of Npu DnaE Enzyme and Microbial Technology (2018)118:6-12
Rapid development of stable transgene CHO cell lines by CRISPR/Cas9 mediated site-specific integration into C12orf35 Applied Microbiology and Biotechnology (2018)102:6105-6117
Enhanced production of anti-PD1 antibody in CHO cells through transient co-transfection with anti-apoptotic genes Bcl-xL and Mcl-1 Bioprocess and Biosystems Engineering (2018)41:633-640
Local and Global Anatomy of Antibody-Protein Antigen Recognition Journal of Molecular Recognition (2018)31,issue 5:e2693
Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patients BBA - Molecular Basis of Disease (2018)6 Pt B:2294-2303
Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system Scientific Reports (2017)7, Article number:8630
Purification of Inclusion Bodies Using PEG Precipitation under Denaturing Conditions to Produce Recombinant Therapeutic Proteins from Escherichia coli Appl Microbiol Biotechnol (2017)101:5267-5278

Producing defucosylated antibodies with
enhanced in vitro antibody-dependent cellular
cytotoxicity via FUT8 knockout CHO-S cells

Engineering in Life Sciences (2017)17:801-808
Production process reproducibility and product quality consistency of transient gene expression in HEK293 cells with anti-PD1 antibody as the model protein Applied Microbiology and Biotechnology (2017)101:1889-1898
A novel self-cleavable tag Zbasic-∆I-CM and its application in the soluble expression of recombinant human interleukin-15 in Escherichia coli Applied Microbiology and Biotechnology (2017)101:1133-1142
Functional knockout of FUT8 in Chinese hamster ovary cells using CRISPR/Cas9 to produce a defucosylated antibody Engineering in life science (2015)15:660-666

 

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